
ELK Biotechnology Erbin (phospho Tyr1104) rabbit pAb
Erbin (phospho Tyr1104) rabbit polyclonal antibody는 인간, 생쥐, 랫트 시료에서 인산화된 Erbin 단백질 검출에 적합합니다. Western blot 및 ELISA에 사용 가능하며, 고순도 IgG 형태로 제공됩니다. ERBB2 기능 조절 및 Ras 신호 경로 연구에 유용합니다.
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제품명
Erbin (phospho Tyr1104) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
Erbin (phospho Tyr1104) rabbit polyclonal antibody는 인간 Erbin 단백질의 Tyr1104 인산화 부위를 인식하도록 설계된 항체입니다. ERBB2 단백질과 상호작용하며 세포 접합부 및 기저측막 등 다양한 세포 위치에서 발현되는 Erbin 단백질 연구에 활용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB2IP; ERBIN; KIAA1225; LAP2; Protein LAP2; Densin-180-like protein; Erbb2-interacting protein; Erbin |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Erbin (phospho Tyr1104) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 172 kD |
| GeneID (Human) | 55914 |
| Human Swiss-Prot No | Q96RT1 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cell junction, hemidesmosome, nucleus membrane, basolateral cell membrane. Found in hemidesmosomes (cell-substrate adhesion complexes in stratified epithelia). In transfected cells, either diffusely distributed over cytoplasm or concentrated at basolateral membrane. Colocalizes with adrenergic receptors ADREN1A and ADREN1B at nuclear membrane of cardiac myocytes (By similarity). |
Background
This gene belongs to the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of ERBB2 and regulates its function and localization. It also influences the Ras signaling pathway by disrupting Ras-Raf interaction. Multiple alternatively spliced transcript variants encoding different isoforms have been reported.
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