ELK Biotechnology EphA2 (phospho Tyr588) rabbit pAb
EphA2 (phospho Tyr588) rabbit polyclonal antibody는 인간 및 마우스 시료에서 EphA2 단백질의 인산화 상태를 검출합니다. Western blot과 ELISA에 적합하며, 고특이성 IgG 형식으로 제공됩니다. 세포막 및 세포 접촉 부위에서 EphA2 단백질을 탐지하는 연구에 유용합니다.
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EphA2 (phospho Tyr588) rabbit pAb
공급업체: ELK Biotechnology
제품명: EphA2 (phospho Tyr588) rabbit polyclonal antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human EphA2 (phospho Tyr588) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kD |
| GeneID (Human) | 1969 |
| Human Swiss-Prot No | P29317 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Cell projection, ruffle membrane; Single-pass type I membrane protein.
Cell projection, lamellipodium membrane; Single-pass type I membrane protein.
Cell junction, focal adhesion. Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311).
Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797).
배경 (Background)
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats.
The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders. [provided by RefSeq, May 2010]
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