ELK Biotechnology eIF4E (phospho Ser209) rabbit pAb
인간 eIF4E의 Ser209 인산화 부위를 인식하는 rabbit polyclonal 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포 내 위치 연구 및 종양 발생 관련 단백질 분석에 활용 가능하며, 고순도 IgG 형태로 제공됩니다.
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제품명
eIF4E (phospho Ser209) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human eIF4E around the phosphorylation site of Ser209 (AA range: 168–217) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| GeneID (Human) | 1977 |
| Human Swiss-Prot No | P06730 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, P-body, Stress granule, Nucleus.
Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732).
Imported into the nucleus via interaction with EIF4ENIF1/4E-T through a piggy-back mechanism (PubMed:10856257).
배경 정보
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5′ end of messenger RNAs.
It aids in translation initiation by recruiting ribosomes to the 5′-cap structure.
Association of this protein with the 4F complex is the rate-limiting step in translation initiation.
This gene acts as a proto-oncogene, and its expression and activation are associated with transformation and tumorigenesis.
Several pseudogenes of this gene are found on other chromosomes.
Alternative splicing results in multiple transcript variants. (RefSeq, Sep 2015)
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