ELK Biotechnology eIF2α (phospho Ser51) rabbit pAb
Human eIF2α 인산화형(Ser51)을 인식하는 rabbit polyclonal antibody로, IF, WB, IHC, ELISA에 적합. 세포질 및 스트레스 과립에 위치하며 단백질 합성 조절 연구에 유용. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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eIF2α (phospho Ser51) Rabbit Polyclonal Antibody
제품 개요
본 항체는 인간 eIF2α의 Ser51 인산화 부위를 인식하는 rabbit polyclonal antibody로, 단백질 합성 조절 및 스트레스 반응 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | eIF2α (phospho Ser51) rabbit pAb |
| Alternative Names | EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human eIF2α around phosphorylation site of Ser51 (AA range: 21–70) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| GeneID (Human) | 1965 |
| Human Swiss-Prot No | P05198 |
| Cellular Localization | Cytoplasm, Stress granule. Colocalizes with NANOS3 in stress granules. |
| Species Reactivity | Human; Mouse; Rat; Dog; Pig; Fish |
Background
Translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of three nonidentical subunits: EIF2-alpha (36 kD, EIF2S1), EIF2-beta (38 kD, EIF2S2), and EIF2-gamma (52 kD, EIF2S3). The rate of ternary complex formation is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954], supplied by OMIM, Feb 2010).
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