ELK Biotechnology EGFR (phospho Thr693) rabbit pAb
EGFR 단백질의 Thr693 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포막, 핵막 등 다양한 세포 내 위치에서 EGFR 검출에 적합.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology EGFR (phospho Thr693) rabbit pAb
제품명
EGFR (phospho Thr693) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Thr693. AA range: 661–710 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kDa |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane; Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the protein kinase superfamily. It acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Ligand binding induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer. (RefSeq, Jun 2016)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.