ELK Biotechnology Cyclin E1 (phospho Thr395) rabbit pAb
Cyclin E1 인산화 Thr395 부위에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포주기 G1/S 전이 조절 연구에 적합하며, 사람, 생쥐, 랫트에 반응. 핵 내 단백질 검출용으로 고품질 신뢰성 제공.
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Cyclin E1 (phospho Thr395) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cyclin E1 (phospho Thr395) rabbit pAb |
| Alternative Names | CCNE1; CCNE; G1/S-specific cyclin-E1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cyclin E1 around the phosphorylation site of Thr395 (AA range: 361–410) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kDa |
| Gene ID (Human) | 898 |
| Human Swiss-Prot No. | P24864 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance through the cell cycle. Cyclins regulate CDK kinases, and distinct cyclins exhibit specific expression and degradation patterns that coordinate mitotic events temporally.
Cyclin E1 forms a complex with CDK2, acting as a regulatory subunit essential for the G1/S transition. It accumulates at the G1-S phase boundary and is degraded during S phase. Overexpression of this gene has been observed in many tumors, leading to chromosomal instability and potential tumorigenesis.
This protein also associates with NPAT (nuclear protein mapped to the ATM locus), participating in its phosphorylation.
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