
ELK Biotechnology Connexin 43 (phospho Ser368) rabbit pAb
Connexin 43 (phospho Ser368) rabbit polyclonal antibody로, 인산화된 Ser368 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. 세포막 및 갭 접합 단백질 연구에 적합합니다.
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Connexin 43 (phospho Ser368) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Connexin 43 (phospho Ser368) rabbit pAb |
| Alternative Names | GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Connexin 43 around the phosphorylation site of Ser367 (AA range: 332-381) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kD |
| Gene ID (Human) | 2697 |
| Human Swiss-Prot No. | P17302 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Cell junction, gap junction; Endoplasmic reticulum. Localizes at the intercalated disk (ICD) in cardiomyocytes, and the proper localization at ICD is dependent on TMEM65. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia, and heart malformations.
[Provided by RefSeq, May 2014]
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