ELK Biotechnology Chk2 (phospho Thr68) rabbit pAb
DNA 손상 반응 관련 세포주기 조절 단백질 Chk2의 Thr68 인산화 형태를 인식하는 rabbit polyclonal antibody. IF, WB, IHC, ELISA에 사용 가능. 높은 특이성과 재현성 제공. 인체, 마우스, 랫트 반응성.
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제품명
Chk2 (phospho Thr68) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
Chk2 (phospho Thr68) rabbit polyclonal antibody는 DNA 손상 반응 및 세포주기 조절에 중요한 Chk2 단백질의 Thr68 인산화 부위를 특이적으로 인식합니다. 본 항체는 다양한 응용 분야에서 높은 민감도와 특이성을 제공합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Alternative Names | CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2 |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68 (AA range: 35–84) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 61 kDa |
| Gene ID (Human) | 11200 |
| Human Swiss-Prot No. | O96017 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 2: Nucleus; Isoform 10: Throughout cell; Isoform 4, 7, 9, 12: Nucleus; Nucleus, PML body, nucleoplasm; recruited into PML bodies with TP53 |
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through control of critical regulators. The encoded protein is a checkpoint regulator and putative tumor suppressor containing a forkhead-associated domain essential for activation upon DNA damage. It is rapidly phosphorylated in response to replication stress and DNA damage. Activated Chk2 inhibits CDC25C phosphatase to prevent mitotic entry and stabilizes p53, leading to G1 arrest. It also phosphorylates BRCA1 to promote survival after DNA damage. Mutations in this gene are linked to Li-Fraumeni syndrome, a familial cancer predisposition condition.
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