ELK Biotechnology Chk2 (phospho Ser516) rabbit pAb
Chk2 (phospho Ser516) rabbit pAb는 DNA 손상 반응 연구용 항체로, 인산화된 Ser516 부위를 인식합니다. Western blot 및 ELISA에 적합하며, 인간 및 원숭이 시료에 반응합니다. 세포주기 조절 및 종양 억제 단백질 연구에 활용 가능합니다.
- 판매단위
- pk
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제품명
Chk2 (phospho Ser516) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Chk2 around the phosphorylation site of Ser516. AA range: 486-535 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 61 kD |
| Gene ID (Human) | 11200 |
| Human Swiss-Prot No. | O96017 |
| Species Reactivity | Human; Monkey |
| Cellular Localization | [Isoform 2]: Nucleus. Isoform 10 is present throughout the cell. [Isoform 4]: Nucleus. [Isoform 7]: Nucleus. [Isoform 9]: Nucleus. [Isoform 12]: Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Recruited into PML bodies together with TP53. |
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein inhibits CDC25C phosphatase, preventing entry into mitosis, and stabilizes the tumor suppressor protein p53, leading to cell cycle arrest in G1. Additionally, it interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a familial cancer phenotype associated with inherited mutations.
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