ELK Biotechnology Cdc2 (phospho Thr161) rabbit pAb
Cdc2 (phospho Thr161) rabbit pAb는 인간 CDC2 단백질의 인산화 Thr161 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 세포 주기 조절 연구에 유용합니다. 사람, 마우스, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Cdc2 (phospho Thr161) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDC2 around the phosphorylation site of Thr161 (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| Gene ID (Human) | 983 |
| Human Swiss-Prot No. | P06493 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm, Mitochondrion, Cytoskeleton (microtubule organizing center, centrosome, spindle). Cytoplasmic during interphase. Colocalizes with SIRT2 on centrosome during prophase and on spindle fibers during metaphase. Translocates to nucleus when phosphorylated before G2-M transition with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA damage. |
Background
Cyclin dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family and serves as the catalytic subunit of the M-phase promoting factor (MPF), essential for G1/S and G2/M phase transitions in the eukaryotic cell cycle. Mitotic cyclins associate with CDK1 as regulatory subunits. The kinase activity of CDK1 is regulated by cyclin accumulation and degradation, as well as phosphorylation and dephosphorylation events that control cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Mar 2009).
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