ELK Biotechnology ATF-2 (phospho Ser112) rabbit pAb
ATF-2 (phospho Ser112) rabbit pAb는 인산화된 ATF-2 단백질을 검출하기 위한 폴리클로날 항체로, WB, IHC, IF, IP, ELISA에 사용 가능. 사람, 생쥐, 랫트 시료에 반응하며, 높은 특이성과 재현성을 제공. -20°C에서 1년 보관 가능.
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제품명
ATF-2 (phospho Ser112) rabbit pAb
대체명 (Alternative Names)
ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein
응용 분야 (Applications)
- WB (Western Blot)
- IHC (Immunohistochemistry)
- IF (Immunofluorescence)
- IP (Immunoprecipitation)
- ELISA
권장 희석 배수 (Recommended Dilutions)
- Western Blot: 1/500 - 1/2000
- Immunohistochemistry: 1/100 - 1/300
- Immunoprecipitation: 2–5 µg/mg lysate
- ELISA: 1/20000
- Other applications: Not yet tested
면역원 (Immunogen)
The antiserum was produced against synthesized peptide derived from human ATF2 around the phosphorylation site of Ser112 or 94.
AA range: 79–128
제품 사양 (Specifications)
| 항목 | 내용 |
|---|---|
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 1386 |
| Human Swiss-Prot No | P15336 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치 (Cellular Localization)
Nucleus, Cytoplasm, Mitochondrion outer membrane.
Shuttles between the cytoplasm and nucleus; heterodimerization with JUN is essential for nuclear localization.
Cytoplasmic localization observed under stress or disease conditions.
Localizes at mitochondrial outer membrane in response to genotoxic stress.
Phosphorylation at Thr-52 required for nuclear localization and negatively regulates mitochondrial localization.
Co-localizes with MRN complex in IR-induced foci (IRIF).
배경 (Background)
Activating transcription factor 2 (ATF2) is a transcription factor belonging to the leucine zipper family of DNA-binding proteins.
It acts as a moonlighting protein with distinct mechanistic functions.
ATF2 binds to the cAMP-responsive element (CRE) and forms homodimers or heterodimers with c-Jun to stimulate CRE-dependent transcription.
It also functions as a histone acetyltransferase (HAT), acetylating histones H2B and H4, thereby influencing chromatin structure and transcriptional activation.
Additionally, ATF2 is involved in the cellular DNA damage response, independent of its transcriptional role.
Several alternatively spliced transcript variants have been identified (RefSeq, Jan 2014).
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배송/결제/교환/반품 안내
배송 정보
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