ELK Biotechnology Akt2 (phospho Ser474) rabbit pAb
Akt2 (phospho Ser474) rabbit pAb는 인간 Akt2 인산화 부위(Ser474)에 특이적인 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 고순도 IgG 형태로 제공됩니다. 세포막 및 핵 내 Akt2 검출에 유용합니다.
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Akt2 (phospho Ser474) Rabbit Polyclonal Antibody
제품 개요
Akt2 (phospho Ser474) rabbit pAb는 인간 Akt2 단백질의 Ser474 인산화 부위를 인식하는 폴리클로날 항체입니다. 세포 내 Akt2의 위치 및 발현 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Akt2 (phospho Ser474) rabbit pAb |
| Alternative Names | AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Akt2 around the phosphorylation site of Ser474 (AA range: 432–481) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 208 |
| Human Swiss-Prot No. | P31751 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, nucleus, cell membrane (peripheral membrane protein), early endosome.
Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts.
Recruited to plasma membrane regions enriched in PI(3,4,5)P3 or PI(3,4)P2 via the N-terminal PH domain.
Cell membrane targeting facilitated by interaction with CLIP3.
Colocalizes with WDFY2 in early endosomes (By similarity).
배경 정보
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like domains.
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors.
Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
The encoded protein is a general protein kinase capable of phosphorylating several known proteins.
[Provided by RefSeq, Jul 2008]
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