ELK Biotechnology Akt2 (phospho Ser474) rabbit pAb

Akt2 (phospho Ser474) Rabbit Polyclonal Antibody

제품 개요

Akt2 (phospho Ser474) rabbit pAb는 인간 Akt2 단백질의 Ser474 인산화 부위를 인식하는 폴리클로날 항체입니다. 세포 내 Akt2의 위치 및 발현 연구에 활용됩니다.

제품 정보

세포 내 위치

Cytoplasm, nucleus, cell membrane (peripheral membrane protein), early endosome.
Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts.
Recruited to plasma membrane regions enriched in PI(3,4,5)P3 or PI(3,4)P2 via the N-terminal PH domain.
Cell membrane targeting facilitated by interaction with CLIP3.
Colocalizes with WDFY2 in early endosomes (By similarity).

배경 정보

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like domains.
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors.
Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
The encoded protein is a general protein kinase capable of phosphorylating several known proteins.
[Provided by RefSeq, Jul 2008]