ELK Biotechnology HSP70 (Acetyl Lys246) rabbit pAb
HSP70 (Acetyl Lys246) rabbit polyclonal antibody로 인간, 랫, 마우스 시료에 반응. Western blot 및 ELISA에 적합하며, 단백질 안정화 및 폴딩 연구에 활용 가능. -20°C에서 1년 보관 가능.
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제품명
HSP70 (Acetyl Lys246) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 HSP70 단백질의 K246 아세틸화 부위를 기반으로 합성된 펩타이드를 면역원으로 사용하여 제작된 rabbit polyclonal antibody입니다. 세포 내 단백질 안정화, 폴딩 및 ubiquitin-proteasome 경로 연구에 유용합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | HSPA1A; HSPA1; HSPA1B; Heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized acetyl-peptide derived from the internal region of human HSP70 around the acetylation site of K246 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| GeneID (Human) | 3303 / 3304 |
| Human Swiss-Prot No | P0DMV8 / P0DMV9 |
| Cellular Localization | Cytoplasm, Nucleus, Cytoskeleton (microtubule organizing center, centrosome), Secreted, Cytoplasmic mRNP granules containing untranslated mRNAs |
| Species Reactivity | Human; Rat; Mouse |
Background
This intronless gene encodes a 70 kDa heat shock protein belonging to the HSP70 family. In conjunction with other heat shock proteins, it stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. It also participates in the ubiquitin-proteasome pathway through interaction with AU-rich element RNA-binding protein 1. The gene is located in the MHC class III region, clustered with two related genes encoding similar proteins. (RefSeq, Jul 2008)
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