ELK Biotechnology HMG-1 (Acetyl Lys12) rabbit pAb
HMG-1 (Acetyl Lys12) rabbit polyclonal antibody로, 인간 HMG-1의 K12 아세틸화 부위에 특이적입니다. WB, IHC, IF, ELISA에 적합하며, 핵 및 세포질 단백질 검출에 활용됩니다. 고순도 IgG로 -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology HMG-1 (Acetyl Lys12) rabbit pAb
제품명
HMG-1 (Acetyl Lys12) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized acetyl-peptide derived from the N-terminal region of human HMG-1 around the acetylation site of K12 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | About 30 kDa |
| GeneID (Human) | 3146 |
| Human Swiss-Prot No | P09429 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane (Peripheral membrane protein, Extracellular side), Endosome, Endoplasmic reticulum-Golgi intermediate compartment.
In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460).
Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940).
Release from macrophages in the extracellular milieu requires activation of NLRC4 or NLRP3 inflammasomes (By similarity).
Passively released from necrotic cells by diffusion, involving fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284).
Also released from apoptotic cells (PubMed:16855214, PubMed:18631454).
Active secretion from a variety of immune cells.
Background
This gene encodes a protein belonging to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription and is involved in DNA organization. It plays roles in inflammation, cell differentiation, and tumor cell migration. Multiple pseudogenes have been identified. Alternative splicing results in multiple transcript variants encoding the same protein.
[Provided by RefSeq, Sep 2015]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.