ELK Biotechnology NFκB-p65 (Acetyl Lys314/Lys315) rabbit pAb
NFκB-p65 (Acetyl Lys314/Lys315) rabbit polyclonal antibody로, 인간, 마우스, 랫트 시료에 반응합니다. WB, IHC, IF, ELISA에 적합하며, 핵 내 NFκB 활성 조절 연구에 유용합니다. 합성 아세틸 펩타이드 면역원으로 제작되었습니다.
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제품명
NFκB-p65 (Acetyl Lys314/Lys315) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized acetyl-peptide derived from the human NFκB-p65 around the acetylation site of K314/K315 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 5970 |
| Human Swiss-Prot No. | Q04206 |
| Cellular Localization | Nucleus, Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L. monocytogenes infection (PubMed:20855622). |
| Species Reactivity | Human; Mouse; Rat |
Background
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. (Provided by RefSeq, Sep 2011)
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