ELK Biotechnology p53 (Acetyl Lys373) rabbit pAb
p53 단백질의 Lys373 아세틸화 형태를 인식하는 rabbit polyclonal 항체. WB 및 ELISA에 적합하며, 세포 내 p53의 위치 및 발현 연구에 활용 가능. 인간, 생쥐, 랫트 반응성. -20℃에서 1년 보관.
- 카탈로그번호
- ES1121-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology p53 (Acetyl Lys373) rabbit pAb
제품명
p53 (Acetyl Lys373) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized acetyl-peptide derived from the human p53 around the acetylation site of K373 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
- Isoform 1: Predominantly nuclear, but localizes to cytoplasm when co-expressed with isoform 4
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) is a tumor suppressor protein with transcriptional activation, DNA binding, and oligomerization domains. It regulates expression of target genes in response to cellular stress, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in TP53 are linked to various human cancers, including hereditary syndromes such as Li-Fraumeni syndrome.
Alternative splicing and use of alternate promoters generate multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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