ELK Biotechnology p53 (Acetyl Lys372) rabbit pAb
인간 p53 단백질의 Lys372 아세틸화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며, 53kDa 밴드 검출. 인간, 생쥐, 랫트 반응성. -20°C에서 1년 보관 가능.
- 카탈로그번호
- ES1111-xxxxx (2개 옵션)
- 판매단위
- pk
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p53 (Acetyl Lys372) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | p53 (Acetyl Lys372) rabbit pAb |
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized Acetyl-peptide derived from human p53 around the Acetylation site of Lys372 (AA range: 331–380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kDa |
| GeneID (Human) | 7157 |
| Human Swiss-Prot No | P04637 |
| Species Reactivity | Human; Rat; Mouse |
Cellular Localization
Cytoplasm, nucleus, PML body, endoplasmic reticulum, mitochondrion matrix, cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
- Isoform 1: Predominantly nuclear, localizes to cytoplasm when expressed with isoform 4
- Isoform 2: Mainly nuclear, minor staining in cytoplasm
- Isoform 3: Nuclear in most cells, cytoplasmic in some cells
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) in Homo sapiens encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.
This protein responds to diverse cellular stresses to regulate target gene expression, leading to cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations are associated with various human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Alternative splicing and promoter usage result in multiple transcript variants and isoforms.
Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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