
ELK Biotechnology p53 (Acetyl Lys370) rabbit pAb
인간, 쥐, 마우스에 반응하는 p53 (Acetyl Lys370) 폴리클로날 항체로 WB, IHC, IF, ELISA에 사용 가능. 합성 아세틸 펩타이드 면역원으로 제작되었으며, 53kD 밴드 검출. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology p53 (Acetyl Lys370) rabbit pAb
제품명
p53 (Acetyl Lys370) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 p53 단백질의 Lys370 아세틸화 부위를 인식하는 폴리클로날 항체로, 다양한 종(인간, 쥐, 마우스)에 반응합니다. 세포 내 위치는 핵, 세포질, PML body, 미토콘드리아 등으로 보고되었습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–300 ELISA: 1/20000 Other applications: Not yet tested |
| Immunogen | Synthesized Acetyl-peptide derived from human p53 around Lys370 (AA range: 331–380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| GeneID (Human) | 7157 |
| Human Swiss-Prot No | P04637 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Centrosome. Translocates to mitochondria upon oxidative stress or mitomycin C treatment. Various isoforms show nuclear and cytoplasmic localization patterns. |
Background
Tumor protein p53 (TP53) is a tumor suppressor that contains transcriptional activation, DNA binding, and oligomerization domains. It regulates target gene expression in response to cellular stress, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes. Mutations in TP53 are associated with many human cancers, including hereditary Li-Fraumeni syndrome. Alternative splicing and promoter usage result in multiple transcript variants and isoforms. Additional isoforms may arise from alternative translation initiation codons (RefSeq, Feb 2013).
ELK Biotechnology 상품 둘러보기
전체보기문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.
