ELK Biotechnology E2F-4 (Acetyl Lys96) rabbit pAb
E2F-4 (Acetyl Lys96) rabbit pAb는 인간 E2F4의 Lys96 아세틸화 부위를 인식하는 폴리클로날 항체입니다. WB와 ELISA에 적합하며, 세포핵 내 E2F4 단백질 검출에 사용됩니다. 고순도 IgG 형식으로 제공되며 -20°C에서 1년 보관 가능합니다.
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제품명
E2F-4 (Acetyl Lys96) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | E2F-4 (Acetyl Lys96) rabbit pAb |
| Alternative Names | E2F4; Transcription factor E2F4; E2F-4 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized Acetyl-peptide derived from human E2F4 around the Acetylation site of Lys96. (AA range: 61–110) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kDa |
| Gene ID (Human) | 1874 |
| Human Swiss-Prot No | Q16254 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins, and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionarily conserved domains, including:
- A DNA binding domain
- A dimerization domain for interaction with DP proteins
- A transactivation domain enriched in acidic amino acids
- A tumor suppressor protein association domain embedded within the transactivation domain
This protein binds to all three tumor suppressor proteins (pRB, p107, and p130), showing higher affinity to p107 and p130. It plays an important role in the suppression of proliferation-associated genes.
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