ELK Biotechnology Histone H3 (Di Methyl Lys10) rabbit pAb
Histone H3 (Di Methyl Lys10) rabbit polyclonal antibody for WB, IHC, IF, ELISA applications. Recognizes di-methylation at K10 site of human Histone H3. High specificity and sensitivity with nuclear localization. Suitable for human, mouse, and rat samples.
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Histone H3 (Di Methyl Lys10) rabbit pAb
제품 개요
Histone H3 (Di Methyl Lys10) rabbit polyclonal antibody는 인간 Histone H3 단백질의 N-말단 영역에서 K10 위치의 이중 메틸화 부위를 인식하도록 설계되었습니다. 염색체 구조 형성 및 유전자 발현 조절 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Histone H3 (Di Methyl Lys10) rabbit pAb |
| Alternative Names | H3K10ME2; HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; H3F3A; H3.3A; H3F3B; H3.3B; Histone H3.3; 등 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000; IHC-p: 1/100–300; ELISA: 1/10000 |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Histone H3 around the di-methylation site of K10 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 17 kDa |
| GeneID (Human) | 8350, 8351, 8352, 8353, 8354, 8355, 8356, 8357, 8358, 8968, 126961, 333932, 653604, 3020, 3021, 440093 |
| Human Swiss-Prot No | P68431, Q71DI3, P84243, Q6NXT2 |
| Cellular Localization | Nucleus; Chromosome |
| Species Reactivity | Human; Mouse; Rat |
Background
Histones are basic nuclear proteins responsible for the nucleosome structure of chromosomal fibers in eukaryotes. Each nucleosome consists of approximately 146 bp of DNA wrapped around an octamer composed of pairs of H2A, H2B, H3, and H4 core histones. The chromatin fiber is further compacted through interactions with linker histone H1, forming higher-order chromatin structures. The Histone H3 gene is intronless and encodes a replication-dependent histone found in the large histone gene cluster on chromosome 6p22-p21.3. Transcripts from this gene lack polyA tails and contain a palindromic termination element.
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