ELK Biotechnology p53 (Di Methyl Lys370) rabbit pAb
Human p53 단백질의 Lys370 이중 메틸화 부위를 인식하는 rabbit polyclonal antibody. IF, WB, IHC, ELISA 등 다양한 응용 가능. 고순도 IgG, 1 mg/ml 농도. -20°C에서 1년 안정 저장.
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제품명
p53 (Di Methyl Lys370) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
본 항체는 인간 p53 단백질의 Lys370 이중 메틸화 부위를 인식하는 rabbit polyclonal antibody로, 암 억제 단백질 p53 관련 연구에 적합합니다.
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC-p: 1:100–300 ELISA: 1:20000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human p53 around the di-methylation site of K370 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| GeneID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton, Centrosome.
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and mitomycin C treatment (PubMed:27323408).
Isoform-specific localization:
- Isoform 1: Nucleus and Cytoplasm
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear, translocates to cytoplasm when co-expressed with isoform 1
Background
Tumor protein p53 (TP53) is a tumor suppressor containing transcriptional activation, DNA binding, and oligomerization domains.
It responds to cellular stress by regulating target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations are associated with various cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and promoter usage produce multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[provided by RefSeq, Feb 2013]
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