ELK Biotechnology Cleaved-Plasma Kallikrein HC (R390) rabbit pAb
Cleaved-Plasma Kallikrein HC (R390) rabbit polyclonal antibody로, 인간 KLKB1 유래 펩타이드를 면역원으로 제작되었습니다. WB, IHC, IF, ELISA에 사용 가능하며, 다양한 종(Human, Rat, Mouse)에 반응합니다. 혈액 응고 및 염증 반응 연구에 적합합니다.
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Cleaved-Plasma Kallikrein HC (R390) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Plasma Kallikrein HC (R390) rabbit pAb |
| Alternative Names | KLKB1; KLK3; Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human KLKB1 (AA range: 341–390) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| GeneID (Human) | 3818 |
| Human Swiss-Prot No. | P03952 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation, and inflammation. The encoded preproprotein, present in plasma as a non-covalent complex with high molecular weight kininogen, undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
[provided by RefSeq, Jan 2016]
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