ELK Biotechnology Cleaved-Factor XII HC (R372) rabbit pAb
Cleaved-Factor XII HC (R372) rabbit pAb는 인간, 랫드, 마우스에서 반응하는 다클론 항체로, WB 및 ELISA에 적합합니다. 혈액 응고 인자 XII 단백질 인식에 사용되며, -20°C에서 1년간 안정적으로 보관 가능합니다.
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Cleaved-Factor XII HC (R372) rabbit pAb
제품 개요
Cleaved-Factor XII HC (R372) rabbit pAb는 인체 FA12 유래 합성 펩타이드(AA 323-372)에 대해 생성된 다클론 항체입니다. 혈액 응고 인자 XII의 절단형 단백질을 검출하는 데 사용되며, Western Blot(WB) 및 ELISA 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Factor XII HC (R372) rabbit pAb |
| Alternative Names | F12; Coagulation factor XII; Hageman factor; HAF |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human FA12 (AA 323–372) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 41 kDa |
| Gene ID (Human) | 2161 |
| Human Swiss-Prot No. | P00748 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes coagulation factor XII, which circulates in blood as a zymogen. This single-chain zymogen is converted to a two-chain serine protease with a heavy chain (α-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two EGF-like domains, a kringle domain, and a proline-rich domain, whereas the light chain contains only a catalytic domain. Upon activation, further cleavages occur in the heavy chain, producing β-factor XIIa. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to α-factor XIIa and subsequently to β-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.
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