ELK Biotechnology Cleaved-Factor VII LC (R212) rabbit pAb
Cleaved-Factor VII LC (R212) rabbit pAb는 인간, 랫, 마우스 시료에서 응고인자 VII 검출용 다클론 항체입니다. WB, IHC, IF, ELISA에 적합하며, 고순도 IgG로 제조되었습니다. 장기보관은 -20°C에서 1년 가능합니다.
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Cleaved-Factor VII LC (R212) rabbit pAb
제품 개요
Cleaved-Factor VII LC (R212) rabbit pAb는 인간 FA7 유래 합성 펩타이드(AA 171-220)를 면역원으로 제작된 토끼 다클론 항체입니다. 응고인자 VII의 절단형을 검출하며, 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Factor VII LC (R212) rabbit pAb |
| Alternative Names | F7; Coagulation factor VII; Proconvertin; Serum prothrombin conversion accelerator; SPCA; Eptacog alfa |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human FA7 (AA range: 171–220) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 17 kDa |
| Gene ID (Human) | 2155 |
| Human Swiss-Prot No | P08709 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes coagulation factor VII, a vitamin K-dependent factor essential for hemostasis. It circulates in the blood as a zymogen and is activated by factor IXa, Xa, XIIa, or thrombin through limited proteolysis. The activated form consists of a heavy chain with a catalytic domain and a light chain with two EGF-like domains linked by a disulfide bond. In the presence of factor III and calcium ions, activated factor VII initiates the coagulation cascade by converting factor IX to IXa and/or factor X to Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [RefSeq, Aug 2015]
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