ELK Biotechnology ICAD rabbit pAb
ICAD rabbit pAb는 인간 DFFA 유래 펩타이드로부터 생산된 다클론 항체로, 세포자멸사 관련 단백질 검출에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용 가능하며, 인간, 랫, 마우스 반응성을 보입니다. 고순도 IgG 형식으로 -20°C에서 1년 보관 가능합니다.
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제품명
ICAD rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ICAD rabbit pAb |
| Alternative Names | DFFA; DFF1; DFF45; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DFFA (AA range: 175–224) |
| Species Reactivity | Human; Rat; Mouse |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 37 kD |
| GeneID (Human) | 1676 |
| Human Swiss-Prot No | O00273 |
| Cellular Localization | Cytoplasm |
Background
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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