ELK Biotechnology Cleaved-Cathepsin G (I21) rabbit pAb
Cleaved-Cathepsin G (I21) rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 CATG 유래 합성 펩타이드로 면역화되었으며, 세포막·세포질·리소좀·핵 등 다양한 위치에서 발현됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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Cleaved-Cathepsin G (I21) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Cathepsin G (I21) rabbit pAb |
| Alternative Names | CTSG; Cathepsin G; CG |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CATG (AA range: 2–51) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 28 + 26 kD |
| GeneID (Human) | 1511 |
| Human Swiss-Prot No | P08311 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cell membrane; Peripheral membrane protein; Cytoplasmic granule; Secreted; Cytoplasm (cytosol); Lysosome; Nucleus.
Secreted by activated neutrophils (PubMed:3390156).
Detected in synovial fluid (PubMed:32144329).
Localizes to lysosomes in B cells where it is internalized from the cell membrane (PubMed:15100291).
Localizes to the nucleus during apoptosis (PubMed:11259672).
Background
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes.
The encoded protease has a specificity similar to chymotrypsin C and may participate in killing and digestion of engulfed pathogens, as well as connective tissue remodeling at sites of inflammation.
Additionally, the encoded protein exhibits antimicrobial activity against S. aureus and N. gonorrhoeae.
Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
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