ELK Biotechnology Cleaved-Cathepsin D HC (L169) rabbit pAb
Cleaved-Cathepsin D HC (L169) rabbit pAb는 인간, 생쥐, 랫트에 반응하는 폴리클로날 항체입니다. Western blot과 ELISA에 적합하며, 합성 펩타이드(AA 150-199)를 면역원으로 사용합니다. 단백질 분해 및 호르몬 활성화 연구에 활용됩니다.
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Cleaved-Cathepsin D HC (L169) rabbit pAb
공급업체: ELK Biotechnology
대체명: CTSD, CPSD, Cathepsin D
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB, ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CATD (AA range: 150–199) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 27 kD |
| GeneID (Human) | 1509 |
| Human Swiss-Prot No. | P07339 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Lysosome, Melanosome, Extracellular space. Identified by mass spectrometry in melanosome fractions (stage I–IV). In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). |
Background
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products, including cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene cause neuronal ceroid lipofuscinosis-10 and may be involved in diseases such as breast cancer and possibly Alzheimer’s disease. (RefSeq, Nov 2015)
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