ELK Biotechnology Cleaved-Caspase-4 p20 (Q81) rabbit pAb
Cleaved-Caspase-4 p20 (Q81) rabbit polyclonal antibody로, 인간 Caspase-4 단백질을 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포자멸사 연구에 적합합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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Cleaved-Caspase-4 p20 (Q81) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Caspase-4 p20 (Q81) rabbit pAb |
| Alternative Names | CASP4; ICH2; Caspase-4; CASP-4; ICE(rel)-II; Protease ICH-2; Protease TX |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase-4 (AA range: 62–111) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 + 22 kDa |
| Gene ID (Human) | 837 |
| Human Swiss-Prot No. | P49662 |
| Cellular Localization | Cytoplasm, cytosol, endoplasmic reticulum membrane (peripheral membrane protein, cytoplasmic side), mitochondrion, inflammasome, secreted. Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). |
| Species Reactivity | Human |
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase can cleave and activate its own precursor protein as well as the caspase-1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. (RefSeq, Jul 2008)
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