ELK Biotechnology Cleaved-Caspase-3 p12 (D175) rabbit pAb
Caspase-3 단백질의 절단형(p12, D175)을 인식하는 토끼 폴리클로날 항체로, 세포 사멸 연구에 활용 가능. WB, IHC, IF, ELISA에 적합하며, 인체·쥐·랫드 시료 반응. 합성 펩타이드 면역원 사용, -20°C에서 1년 보관.
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Cleaved-Caspase-3 p12 (D175) rabbit pAb
제품 개요
Cleaved-Caspase-3 p12 (D175) rabbit pAb는 Caspase-3 단백질의 절단형을 인식하는 토끼 폴리클로날 항체로, 세포 사멸(apoptosis) 과정 연구에 유용합니다. Caspase-3는 cysteine-aspartic acid protease 계열에 속하며, 세포 사멸의 실행 단계에서 중요한 역할을 합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-3 p12 (D175) rabbit pAb |
| Alternative Names | CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
| Applications | WB; IF; IHC; ELISA |
| Recommended Dilutions | WB 1:500–2000, IHC-p 1:50–300, IF 1:50–300 |
| Immunogen | Synthesized peptide derived from human Caspase-3 (AA 157–206) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 12, 35 kDa |
| Gene ID (Human) | 836 |
| Human Swiss-Prot No. | P42574 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small), which dimerize to form the active enzyme. Caspase-3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
[RefSeq, Jul 2008]
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