Thermo Fisher Scientific EXOSC5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MEEETHTDAKI RAENGTGSSP RGPGCSLRHF ACEQNLLSRP DGSASFLQGD TSVLAGVYGP AEVKVSKEI

Highest antigen sequence identity to the following orthologs:

• Mouse: 80%
• Rat: 81%

Target Information

EXOSC5 is a non-catalytic component of the RNA exosome complex with 3'→5' exoribonuclease activity, participating in diverse RNA processing and degradation events.
In the nucleus, it is involved in:

• Maturation of stable RNA species (rRNA, snRNA, snoRNA)
• Elimination of RNA processing by-products and non-coding pervasive transcripts (e.g., antisense RNA, PROMPTs)
• Degradation of defective mRNAs to prevent cytoplasmic export

In the cytoplasm, it functions in:

• General mRNA turnover
• Degradation of unstable mRNAs with AU-rich elements (AREs)
• RNA surveillance to prevent translation of aberrant mRNAs
• Degradation of histone mRNA

The catalytic inactive RNA exosome core complex (Exo-9) acts as a scaffold for RNA binding and presentation for ribonucleolysis and association with catalytic subunits and accessory proteins.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.