Thermo Fisher Scientific PDGFD Monoclonal Antibody (OTI1C1), TrueMAB
인간 PDGFD 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적인 저장용 PBS 버퍼 포함. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–247 of human PDGFD produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The platelet-derived growth factor (PDGF) family consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival, and function in several types of connective tissue cells.
Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-α and PDGFR-β, and PDGF-mediated signaling is critical for development of many organ systems.
PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating proliferation and stimulating tumor neovascularization. It may play a role in brain tumor development and prostate cancer progression.
PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells, and various tumor cell lines including ovarian, renal, lung cancers, astrocytomas, and medulloblastomas. It is also expressed in human kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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