Thermo Fisher Scientific PDGFD Monoclonal Antibody (OTI1C1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Target Information

The platelet-derived growth factor (PDGF) family consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival, and function in several types of connective tissue cells.

Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-α and PDGFR-β, and PDGF-mediated signaling is critical for development of many organ systems.

PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating proliferation and stimulating tumor neovascularization. It may play a role in brain tumor development and prostate cancer progression.

PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells, and various tumor cell lines including ovarian, renal, lung cancers, astrocytomas, and medulloblastomas. It is also expressed in human kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.