Thermo Fisher Scientific beta Catenin Polyclonal Antibody
Thermo Fisher Scientific의 beta Catenin Polyclonal Antibody는 인간, 마우스, 랫트 등에서 반응하며 다양한 응용 분야(WB, IHC, ICC 등)에 사용 가능합니다. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 연구용으로 세포 접착 및 신호전달 관련 단백질 분석에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:20,000 | View 4 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
| Flow Cytometry (Flow) | 1:50–1:200 | – |
| Immunoprecipitation (IP) | 1:50–1:100 | – |
| ChIP assay (ChIP) | Assay-dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human beta Catenin. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.13 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735522 |
Product Specific Information
- Positive Control: HeLa, A549, H1299, HCT116, PC-12, Mouse brain, human fibroblast, LX2
- Predicted Reactivity: Zebrafish (95%), Xenopus laevis (97%), Dog (99%), Pig (99%), Chicken (97%), Sheep (99%), Rhesus Monkey (100%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Beta-catenin is an adherens junction (AJ) protein, originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion. Beta-catenin interacts with E-cadherin and alpha-catenin, linking the E-cadherin complex to the actin cytoskeleton. It also binds to cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless.
Beta-catenin expression is observed in various hair follicle cells and epithelial structures. Pathological roles are reported in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and tumor development. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of cyclin D and c-myc, key regulators of cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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