Thermo Fisher Scientific CD27/TNFRSF7 Polyclonal Antibody

Applications

Product Specifications

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of this family regulate cell proliferation and death. CD27 and its ligand CD70 are mainly expressed in lymphocytes, and high CD27 expression depends on antigen receptor ligation. CD70 expression requires co-stimulatory or pro-inflammatory signals.

CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and some B cells. T cell activation via the TCR-CD3 complex increases CD27 expression and releases soluble CD27 (sCD27, 28–32 kDa), found in plasma, urine, or spinal fluid. Soluble CD27 serves as a prognostic marker for acute and chronic B cell malignancies.

RgpA, a cysteine proteinase, degrades CD27 and counteracts T cell activation mediated by CD27/CD70. CD27-binding protein (SIVA), a proapoptotic protein, binds to CD27 and is involved in CD27-induced apoptosis. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.