Thermo Fisher Scientific MITF Monoclonal Antibody (M2A1)
MITF 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. Human, Mouse, Rat 시료에 반응하며, 단백질 발현 연구 및 세포 분화 연구에 활용됩니다. Protein G로 정제된 액상 항체로 안정적인 저장이 가능합니다.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M2A1 |
| Immunogen | This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage buffer | TBS, pH 7.4, with 40% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells, and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin, eye, and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60–70 kDa in osteoclasts and in B16 melanoma cells (but not other melanoma cell lines), as well as mast cells and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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