Thermo Fisher Scientific TWIST2 Polyclonal Antibody
TWIST2 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TWIST2. Recombinant protein control fragment (Product #RP-107203) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664229 |
Product Specific Information
Immunogen sequence:
ELERQPKRFGR KRRYSKKSSE DGSPTPGKRG KKGSPSAQSF EELQSQRIL
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
TWIST2 binds to the E-box consensus sequence (5'-CANNTG-3') as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C.
It also represses expression of proinflammatory cytokines such as TNFA and IL1B.
TWIST2 is involved in postnatal glycogen storage and energy metabolism, and inhibits premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by altering internal signal transduction responses to growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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