Thermo Fisher Scientific PAPPA2 Polyclonal Antibody
Human PAPPA2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.1 mg/mL 농도의 액상 형태입니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PAPPA2. Recombinant protein control fragment (Product # RP-91867) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645202 |
Product Specific Information
Immunogen sequence:
NPAGLRGAVE EPAAPWVGDS PIGQSELLGD DDAYLGNQRS KESLGEAGIQ KGSAMAATTT TAIFTTLNEP KPETQRRGWA KSRQRRQVWK RRAEDGQGDS GISSHFQPWP KH
Highest antigen sequence identity to orthologs:
- Mouse: 56%
- Rat: 54%
Target Information
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in an IGF-independent manner.
It is suggested that the cleavage of IGFBP-5 and, to a lesser extent, IGFBP-3 produced in the maternal decidua promotes feto-placental growth.
Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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