Thermo Fisher Scientific PAPPA2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PAPPA2. Recombinant protein control fragment (Product #RP-91867). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PAPPA2,uniProtId:Q9BXP8-1,ncbiNodeId:9606,antigenRange:114-225,antigenLength:1791,antigenImageFileName:PA5-53793_PAPPA2_Q9BXP8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53793_PAPPA2_Q9BXP8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645202

Product Specific Information

Immunogen sequence: NPAGLRGAVE EPAAPWVGDS PIGQSELLGD DDAYLGNQRS KESLGEAGIQ KGSAMAATTT TAIFTTLNEP KPETQRRGWA KSRQRRQVWK RRAEDGQGDS GISSHFQPWP KH

Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 54%.

Target Information

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.