Thermo Fisher Scientific IL-17A Polyclonal Antibody, Biotin
IL-17A 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Mouse 및 Rat 시료에 반응. WB, IHC, ELISA 등 다양한 면역분석에 사용 가능. 고순도 정제 및 안정적 보관 용이. 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| ELISA | 1:20,000–1:100,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This purified antibody was prepared from whole rabbit serum produced by repeated immunizations with full length recombinant rat IL17-A protein. |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl, 10 mg/mL BSA |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration.
- For extended storage, aliquot contents and freeze at -20°C or below.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- This product is stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
In ELISA and other immunoreactive assays, this antibody recognizes both native and recombinant rat IL17-A in cell supernatants and certain body fluids. A control of similarly diluted normal rabbit IgG is recommended.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4⁺ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa, disulfide-linked homodimer consisting of 136 amino acids, belonging to a six-member family (IL-17A–F) and signals through the IL-17 receptor (IL-17R/CDw217).
It enhances expression of ICAM-1 in human fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
IL-17A regulates NF-κB and MAPK pathways, stimulates IL-6 and COX-2 (PTGS2) expression, and enhances nitric oxide (NO) production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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