Thermo Fisher Scientific TCOF1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 TCOF1 폴리클로날 항체로 Western blot 및 IHC(Paraffin)에 적합. Rabbit IgG로 제작되었으며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 액상 형태, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 22–73 of Human TCOF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718978 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% (by SDS-PAGE).
Target Information
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. It plays a critical role in early embryonic development, particularly in the craniofacial complex, and may be involved in nucleolar-cytoplasmic transport.
Mutations in TCOF1, the gene encoding Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), characterized by craniofacial developmental defects including conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures, and cleft palate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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