Thermo Fisher Scientific JIP3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human JIP3 protein. Validated for IHC(P) and ICC/IF applications. Purified via antigen affinity chromatography and supplied in PBS with 40% glycerol. Suitable for research on JNK signaling pathways. For research u...
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human JIP3. Recombinant protein control fragment (Product # RP-102915) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642848 |
Product Specific Information
Immunogen sequence:
LDSDVNPEDP GADGVLAGIT LVGCATRCNV PRSNCSSRGD TPVLDKGQGE VATIANGKVN PSQSTEEATE ATEVPDPGPS EPETATLRPG PLTEHVFTDP A
Highest antigen sequence identity to orthologs:
- Mouse: 93%
- Rat: 92%
Target Information
c-Jun NH2-terminal kinases (JNKs) are members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to UV light and phosphorylates c-Jun at Ser63 and Ser73, leading to transcriptional activation.
JIP-1 (JNK interacting protein-1) acts as a cytoplasmic inhibitor of JNK, retaining it in the cytoplasm and inhibiting JNK-regulated gene expression. JIP-1 binds JNK1 and JNK2 with greater affinity than ATF-2 and c-Jun, which are JNK pathway targets.
JIP-1 contains an N-terminal JNK binding domain and a C-terminal SH3 domain. Multiple splice variants, including JIP-1b, JIP-1c (IB-1), JIP-2a, JIP-2b, and JIP-3, are identified in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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