Thermo Fisher Scientific HP1 alpha Monoclonal Antibody (7000)
HP1 alpha 단백질을 인식하는 Mouse IgG 단일클론 항체. Western blot에 최적화되어 있으며 인간, 생쥐, 랫트 반응성. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관. 유전자 발현 조절 및 염색질 구조 연구용.
- 판매단위
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Thermo Fisher Scientific HP1 alpha Monoclonal Antibody (Clone 7000)
Applications
- Western Blot (WB)
Tested Dilution: 1:300
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7000 |
| Immunogen | KLH conjugated synthetic peptide derived from human HP1 alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing. Mammalian methyltransferases that methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which are adaptor molecules involved in gene silencing and chromatin structure.
High-affinity recognition of methylated histone H3 peptide by HP1 requires a functional chromodomain, serving as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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