Thermo Fisher Scientific HP1 alpha Monoclonal Antibody (7000)

Thermo Fisher Scientific HP1 alpha Monoclonal Antibody (Clone 7000)

Applications

• Western Blot (WB)
  Tested Dilution: 1:300

Product Specifications

Target Information

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing. Mammalian methyltransferases that methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which are adaptor molecules involved in gene silencing and chromatin structure.
High-affinity recognition of methylated histone H3 peptide by HP1 requires a functional chromodomain, serving as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.