Thermo Fisher Scientific DELE Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DELE if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DELE,uniProtId:Q14154-1,ncbiNodeId:9606,antigenRange:123-213,antigenLength:515,antigenImageFileName:PA5-57712_DELE_Q14154-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57712_DELE_Q14154-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640508

Product Specific Information

Immunogen sequence: PLDRFFSSPL WHPCSSLRQH ILPSPDGPAP RHTGLREPRL GQEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ P

Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 59%.

Target Information

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.