Thermo Fisher Scientific ERO1L Polyclonal Antibody

Thermo Fisher Scientific ERO1L Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in the ER membrane as a peripheral membrane protein on the lumenal side. Its association with ERP44 is essential for ER retention and uniquely couples oxygen reduction to de novo disulfide formation.
ERO1L is broadly distributed at low levels in several tissues, with highest expression in the upper digestive tract, and is stimulated by hypoxia via HIF signaling. It generally exists as a monomer but can function as a homodimer and interacts with PDILT.
After translation, ERO1L undergoes N-glycosylation; its disulfide bonds form the redox-active center, where the Cys-94/Cys-99 disulfide bond accepts electrons from P4HB and transfers them to the active site disulfide Cys-394/Cys-397.
ERO1L oxidizes directly to P4HB/PDI isomerase through disulfide exchange and associates with ERP44. It is implicated in immunoglobulin folding, oxidative stress response, cholera toxin release upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through IP3R1 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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