Thermo Fisher Scientific ZN692 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZNF692. Recombinant protein control fragment (Product #RP-103352).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649948

Product Specific Information

Immunogen sequence: GLVWECSAGH TFSWGPSLSP TPSEAPKPAS LPHTTRRSWC SEATSGQELA DLESEHDERT QEARLPRRVG PPPETFP

Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 71%.

Target Information

ZNF692, a zinc finger protein, is involved in several cellular processes including nucleolar organization and ribosome biogenesis. It interacts with nucleophosmin (NPM1), regulating nucleolar morphology by modifying NPM1`s self-assembly properties and influencing protein synthesis. Knockdown of ZNF692 causes nucleolar redistribution of NPM1 and results in a decreased rate of protein synthesis. Additionally, ZNF692 plays a role in 40S ribosomal subunit maturation by forming a hub with the exosome complex and ribosome biogenesis factors. This gene is upregulated in certain cancers such as clear cell renal cell carcinoma (ccRCC), where its expression is associated with increased cell proliferation, migration, and poor overall survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.