Thermo Fisher Scientific HORMAD2 Polyclonal Antibody
Thermo Fisher Scientific의 HORMAD2 Polyclonal Antibody는 인간 HORMAD2 단백질에 특이적으로 반응하는 토끼 IgG 항체입니다. Western blot과 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며 안정적인 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- Publications: –
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: –
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HORMAD2. Recombinant protein control fragment (Product #RP-91522) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642518 |
Product Specific Information
Immunogen sequence:
QLSHCITIHK ASKETVFPSQ ITNEHESLKM VKKLFATSIS CITYLRGLFP ESSYGERHLD DLSLKILRED KKCPGSLHII RWIQGCFDAL EKRYLRMAVL TLYTDPMGSE KVTEMYQFKF KYTK
Ortholog sequence identity:
- Mouse: 82%
- Rat: 85%
Target Information
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, forming the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for DNA double-strand break-independent, BRCA1-dependent activation of ATR on sex chromosomes essential for normal sex body formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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