Thermo Fisher Scientific HORMAD2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HORMAD2. Recombinant protein control fragment (Product #RP-91522). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HORMAD2,uniProtId:Q8N7B1-1,ncbiNodeId:9606,antigenRange:5-128,antigenLength:307,antigenImageFileName:PA5-51816_HORMAD2_Q8N7B1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51816_HORMAD2_Q8N7B1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642518

Product Specific Information

Immunogen sequence: QLSHCITIHK ASKETVFPSQ ITNEHESLKM VKKLFATSIS CITYLRGLFP ESSYGERHLD DLSLKILRED KKCPGSLHII RWIQGCFDAL EKRYLRMAVL TLYTDPMGSE KVTEMYQFKF KYTK

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

Target Information

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.