Thermo Fisher Scientific Fascin-1 (Reed-Sternberg Cell Marker) Recombinant Mouse Monoclonal Antibody (rFSCN1/6464)

Thermo Fisher Scientific Fascin-1 (Reed-Sternberg Cell Marker) Recombinant Mouse Monoclonal Antibody (rFSCN1/6464)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Stability: Antibody is stable for 24 months.
• Positive Control: HeLa, MCF-7, PC-3, or BEWO cells; Hodgkin’s lymphoma, ovarian or testicular carcinoma.
• Cellular Localization: Cytoplasm.
• Specificity Comments:
  • Recognizes a 55kDa protein identified as fascin-1.
  • Actin-binding ability is regulated by phosphorylation.
  • Highly sensitive marker for Reed-Sternberg cells and variants in Hodgkin’s disease.
  • Negative in lymphoid, plasma, and myeloid cells.
  • Expressed in dendritic cells.
  • Useful in distinguishing Hodgkin lymphoma from non-Hodgkin lymphoma.
  • Lack of fascin-1 expression helps differentiate follicular lymphoma from reactive follicular hyperplasia.
  • Suggested as a prognostic marker in neuroendocrine lung neoplasms and ovarian cancer.
  • Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells.

Target Information

Fascin organizes filamentous actin into bundles with a minimum 4:1 actin/fascin ratio. It is involved in the assembly of actin filament bundles in microspikes, membrane ruffles, and stress fibers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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