Thermo Fisher Scientific JAK2 Polyclonal Antibody
JAK2 단백질을 표적하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human JAK2 (amino acids 601–700) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. JAK2 contains the catalytic domain (JH1) and participates in phosphorylation of STAT proteins, which regulate transcription of interferon-stimulated genes. It is essential for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier. Mutations in JAK2 are associated with Budd-Chiari syndrome, polycythemia vera, thrombocythemia, myelofibrosis, and acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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