Thermo Fisher Scientific ITCH Polyclonal Antibody
Human ITCH 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제. 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific ITCH Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITCH. Recombinant protein control fragment (Product #RP-91866) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642805 |
Product Specific Information
Immunogen sequence:
LKSDVLLGTA ALDIYETLKS NNMKLEEVVV TLQLGGDKEP TETIGDLSIC LDGLQLESEV VTNGETTCSE NGVSLCLP
Highest antigen sequence identity to the following orthologs:
- Mouse: 79%
- Rat: 79%
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. These proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-54329_ITCH_Q96J02-1_Rabbit.svg, PA5-54329_ITCH_Q96J02-1_Rabbit_PDP.jpeg)
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