Thermo Fisher Scientific ROS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1934-2232 of human ROS1 (NP_0029352?) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ROS1,uniProtId:P08922-1,ncbiNodeId:9606,antigenRange:1934-2232,antigenLength:2347,antigenImageFileName:PA5-110313_ROS1_P08922-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110313_ROS1_P08922-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.02 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855724

Product Specific Information

Immunogen sequence: IENLPAFPRE KLTLRLLLGS GAFGEVYEGT AVDILGVGSG EIKVAVKTLK KGSTDQEKIE FLKEAHLMSK FNHPNILKQL GVCLLNEPQY IILELMEGGD LLTYLRKARM ATFYGPLLTL VDLVDLCVDI SKGCVYLERM HFIHRDLAAR NCLVSVKDYT SPRIVKIGDF GLARDIYKND YYRKRGEGLL PVRWMAPESL MDGIFTTQSD VWSFGILIWE ILTLGHQPYP AHSNLDVLNY VQTGGRLEPP RNCPDDLWNL MTQCWAQEPD QRPTFHRIQD QLQLFRNFFL NSIYKSRDE

Target Information

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.