Thermo Fisher Scientific RIG-I Polyclonal Antibody
RIG-I 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 등 다양한 응용에 적합합니다. 고순도 Affinity chromatography로 정제되었으며, PBS 기반 완충액에 40% glycerol이 포함되어 있습니다. Human 시료 반응성이 검증되었고, 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 143–229). Recombinant protein control fragment (Product #RP-109820) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3092315 |
Product Specific Information
- Immunogen sequence: CSTKGMMAGA EKLVECLLRS DKENWPKTLK LALEKERNKF SELWIVEKGI KDVETEDLED KMETSDIQIF YQEDPECQNL SENSCPP
- Antigen sequence identity: Mouse 67%; Rat 65%
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the recognition of viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both are RNA helicases with overlapping and distinct roles.
RIG-I is activated by short dsRNAs lacking a 5′-triphosphate end, while MDA5 responds to long dsRNAs. Once activated, both signal through IPS-1 to activate transcription factors NF-κB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A/B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a is involved in feedback inhibition of RIG-I-dependent antiviral response by negatively regulating TRAF6, IRAK1, and IRAK2. Recent findings suggest RIG-I also detects cytosolic DNA through RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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