Thermo Fisher Scientific KCNMA1 (KCa1.1) (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C, protected from light, for up to 1 week.
For long-term storage, aliquot and keep at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Potassium channels are ubiquitously expressed proteins involved in various cellular functions.
The large conductance, calcium-activated potassium channel (Maxi K⁺, also known as KCa1.1) is activated by both intracellular calcium increase and membrane depolarization.
The Maxi K⁺ channel consists of an alpha homotetramer forming the pore and a voltage sensor, along with an intracellular calcium-binding domain.
In vascular smooth muscle, an auxiliary beta-subunit associates in a 1:1 ratio, reducing the calcium concentration required for channel activation by 5–10 fold.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.